HBx Mediated Increase of DDX17 Contributes to HBV-Related Hepatocellular Carcinoma Tumorigenesis

HBx Mediated Increase of DDX17 Contributes to HBV-Related Hepatocellular Carcinoma Tumorigenesis

Blog Article

HBV is strongly associated with HCC development and DEAD-box RNA helicase 17 (DDX17) is a very important member of the DEAD box family that plays key roles in HCC development by promoting cancer metastasis.However, the important role of DDX17 in the pathogenesis of HBV-related HCC remains unclear.In this study, we investigated the role of DDX17 in the replication of HBV and Ship Model Kit the development of HBV-associated HCC.

Based on data from the GEO database and HBV-infected cells, we found that DDX17 was upregulated by the HBV viral protein X (HBx).Mechanistically, increased DDX17 expression promoted HBV replication and transcription by upregulating ZWINT.Further study showed that DDX17 could promote HBx-mediated HCC metastasis.

Finally, the promotive effect of DDX17 on HBV and HBV-related HCC was confirmed in click here vivo.In summary, the results revealed the novel role of DDX17 in the replication of HBV and the metastasis of HBV-associated HCC.